Bhrt for Specific Ailments

BHRT- BIO IDENTICAL OR NATURAL HORMONE REPLACEMENT THERAPY

Bio-identical means that the hormones are an exact match to the hormones produced by the human body. They could also be called human-identical, Natural or plant-based.

Current example: Crystalline Insulin, Human Growth Hormone, Bioidentical Testosterone, Estradiol, Estriol, Progesterone, DHEA, melatonin, Prednisolone, Levo Thyroxine, TriiodoThyronine (Pure T3) Armour  eqvivalent compounded Thyroids, Melatonin, etc

Every treatment regimen is custom-tailored to the individual based on the results of blood tests, medical history, physical exam, and symptoms presented. These hormones get their start in nature, found in soy beans and wild yams; they can then be easily converted into the exact hormones that the body makes. The body recognizes these Bio-identical hormones and uses them just as it would if they were being produced by the ovaries, testes, or adrenal glands.

By working with compounding pharmacies, physicians are able to prescribe dosages more precisely and then properly adjust the dosage, in response to symptoms and laboratory findings. In contrast to the Bio-identical hormones; non-bio-identical hormones are not easily accepted by the body, even though they may produce some similar effects. Hormone therapy requires appropriate testing, examination and discussion of symptoms with a healthcare practitioner.

Available BHRT Services

HYPOTHYROIDISM

Common symptoms include abnormal weight gain, chronic fatigue, Falling of hair, Dry Skin, depression and constipation. Hypothyrodism is often associated with PCOS, Insulin Resistance and Diabetes. In many cases the blood tests positive for Thyroid antibodies in which case the condition is known as Autoimmune (Hashimoto’s) Thyroiditis The condition is diagnosed through lab tests and is treated by thyroid hormone replacement therapy, conventional by Levo thyroxine. A more progressive approach to Thyroid replacement is through use of combination of T3 and T4 through dessicated/Armour/Compounded Thyroid. Optimization of Vit D, Vit B12 along with supplementation with appropriate dose of Belle-OMEGA+  =  Fish Oil Omega3 Fatty Acids, Iodine and Probiotics form an integral part of the Comprehensive management of Hypothyroidism through BHRT.

POLYCYSTIC OVARY SYNDROME (STEIN-LEVENTHAL SYNDROME)

  • One of the most common hormonal endocrine disorders in women.Up to 10% of women and girls worldwide have polycystic ovary syndrome.
  • Levels of the sex hormones estrogen and progesterone are out of balance. This leads to the growth of ovarian cysts identifiable in many cases though pelvic Ultrasonography.
  • Irregular menstrual periods, excess hair growth, acne, and obesity can occur in women with polycystic ovary syndrome.
  • The exact cause of polycystic ovary syndrome is unknown but the condition is found to be associated with one or more of the following: Insulin resistance, Vit D deficiency, Vit B12 defficiency, low progesterone level in the leuteal peak, increased testosterone levels, hypothyroidism, abnormal lipid profile.
  • If not adequately managed PCOs it may lead to infertility, Gestational Diabetes, Diabetes Mellitus, depression, anxiety, increased risk of Heart disease, Stroke, breast neoplasm, Endometriosis, Fibroid Uterus, Endometrial carcinoma.
  • Early diagnosis and treatment along with weight loss may reduce the risk of long-term complications.
  • Effective management of PCOS involves identifying and quantifying the hormonal imbalances and nutritional deficiencies and correction of the same.

INFERTILITY

Infertility refers to an inability to conceive after having regular unprotected sex. Infertility can also refer to the biological inability of an individual to contribute to conception, or to a female who cannot carry a pregnancy to full term. In many countries infertility refers to a couple that has failed to conceive after 12 months of regular sexual intercourse without the use of contraception.

Studies indicate that slightly over half of all cases of infertility are a result of female conditions, while the rest are caused by either sperm disorders or unidentified factors.

A woman’s fertility starts to drop after she is about 32 years old, and continues doing so. A 50-year-old man is usually less fertile than a man in his 20s (male fertility progressively drops after the age of 40).

Risk factors for infertility are : Smoking , Alcohol consumption, Being obese or overweight , Eating disorders , Folic acid and Vit B12 deffiency, Over-exercising or Not exercising at all, Sexually transmitted infections, Exposure to some chemicals, Mental stress.

Optimization of Metabolic parameters through BHRT helps in promoting spontaneous conception and improves the success rate of assisted conception. It also helps maintain pregnancy in order to take it to a successful outcome of a healthy mother and child. Specifically T3, Vit B12 and Progesterone play important roles.

MENOPAUSE

Menopause is defined as the absence of menstrual periods for 12 months. The process of menopause is a gradual process. The transition period is called perimenopause. It is important to address the hormonal imbalances during this period, particularly the relative Estrogen dominance. Symptoms of perimenopause, menopause, and postmenopause vary greatly from woman to woman. However, common symptoms of menopause include:

  • Irregular periods
  • Hot flashes, Night sweats
  • Cognitive and Mood changes
  • Fatigue
  • Vaginal dryness and itching
  • Decreased libido and interest in sex.
  • Weight gain
  • Changes in skin texture, worsening ofacne, Hairfall

The average age of menopause is 51 years old, but menopause may occur as early as the 30s or as late as the 60s. If untreated, there is increased risk of typical age-related diseases like, Diabetes, Hypertension, Myocardial Inshemia, Stroke, Osteoporosis, Dementia, ARMD and Cancers.

Perimenopause, Menopause and postmenopause can be effectively and safely addressed by use of bioidentical hormones, Progesterone, Estradiol, Testosterone, DHEA along with optimization of other hormones and Nutrients.

ANDROPAUSE

Men after the age of 40 experience a phenomenon similar to the female menopause, called Andropause caused by a drop in testosterone . Low testosterone levels in men are responsible for the bulk of men’s physical and mental decline.

Symptoms of Andropause:

  • Changes in attitudes and moods,
  • Fatigue, “Pot belly” and decresed physical agility
  • Loss of energy, sex drive.
  • Erectile dysfunction
  • Loss of memory and mental dysfunction
  • Increased incidence of Type II Diabetes

Studies show that this decline in testosterone can actually put one at risk for other health problems like heart disease, osteoprosis and Alzheimer’s.

A gradual hormonal decline, unlike menopause, which generally occurs in women during their mid-forties to mid-fifties, men’s “transition” may be much more gradual and expand over many decades. Attitude, psychological stress, alcohol, injuries or surgery, medications, obesity and infections can contribute to its onset and progression.

Sensitive tests for bioavailable testosterone weren’t available until recently, so andropause has gone through a long period where it was under diagnosed and undertreated. Now that men are living longer, there is heightened interest in andropause and this will help to advance our approach to this important life stage which was identified so long ago.

This situation is changing. New blood testing methods are available and there is an increased interest in mens’ ageing among medical researchers. So much attention is being focused on andropause that major efforts are underway to quickly share emerging scientific information with the international medical community.

The use of bio-Identical hormones, like testosterone, is becoming increasingly popular. Recent studies indicate long-term testosterone replacement therapy is associated with a decreased risk for cardiovascular disease and Prostate Cancer in men, according to a large population-based cohort study. This has been endorsed by American Urological Association in April 2016.The preferred route of administration of Testosterone  is through Transdermal cream compounded in compounding pharmacy. Blood Testosterone  levels and PSA titres should be periodically monitored along with Digital Rectal Examination andultrasonic monitoring of prostate size in selected cases.

OSTEOPOROSIS

  • Declining estrogen, progesterone and Testosterone levels cause bone density to decrease and the risk of fractures to increase. Estrogen is important for bone growth and strength, while progesterone rebuilds new bone cells. Decline in Growth Hormone levels associated with aging also contributes to the progression of Osteoporosis.
  • Hormone replacement therapy (HRT) with estrogen and progesterone is approved for both prevention and treatment of postmenopausal osteoporosis. Estrogen therapy taken alone without being balanced by Natural Progesterone, can increase a woman’s risk of developing cancer in the uterus and breast.
  • Osteoporosis is often associated with inadequate calcium intake. However, a deficiency of vitamin D also contributes to osteoporosis by reducing calcium absorption. According to the National Institutes of Health (USA), people with vitamin D insufficiency absorb less than 10% of available calcium. The study concluded that there was a lower risk of hip fractures only in individuals with a higher intake of calcium coupled with a higher intake of vitamin D.
  • One fifth of hip fractures occur in men. The exponential increase in hip fractures with age is seen in both genders, but the rise occurs about 10 years later in men than in women. Males lose bone density with aging, but because males begin with a higher bone density, they reach osteoporotic levels at an older age than females. Also, men do not undergo the rapid bone loss associated with menopause. By the age of 90, about 17% of males have had a hip fracture, compared to 32% of females.

Other treatment:

  1. Bisphosphonates
  2. Teriparatide (Anabolics from the class of PTH): This is a choice for men with severe osteoporosis who has not responded to other therapies.
  3. Calcitonin: This has not been extensively studied but it is reasonable to use this agent in mild cases or as a second choice if side effects prevent other choices.
  4. Thiazides: This drug is not usually recommended primarily for prevention of osteoporosis because the appropriate studies for fracture prevention have never been done
  5. HGH Injection therapy in case of Adult Growth Hormone Deficiency

Basic prevention of Osteoporosis:

  • Adequate calcium, vitamin D
  • Exercise, optimal weight
  • Avoidance of smoking
  • Timely supervised replacement of sex hormones through BHRT

CHRONIC FATIGUE SYNDROME (CFS)

Chronic fatigue syndrome (CFS) is a complicated disorder characterized by extreme fatigue that can’t be explained by any underlying medical condition. The fatigue may worsen with physical or mental activity, but doesn’t improve with rest.

The cause of CFS is unknown, although there are many theories — ranging from viral infections to psychological stress. Some experts believe chronic fatigue syndrome might be triggered by a combination of factors. There’s no single test to confirm a diagnosis of CFS. You may need a variety of medical tests to rule out other health problems that have similar symptoms. Treatment for chronic fatigue syndrome focuses on symptom relief.

Clinical presentation of CFS consists of the following symptoms

  • Fatigue
  • Loss of memory or concentration
  • Sore throat
  • Enlarged lymph nodes in your neck or armpits
  • Unexplained muscle pain
  • Pain that moves from one joint to another without swelling or redness
  • Headache of a new type, pattern or severity
  • Unrefreshing sleep
  • Extreme exhaustion lasting more than 24 hours after physical or mental exercise

People who have chronic fatigue syndrome also sometimes experience abnormal blood levels of hormones produced in the hypothalamus, pituitary glands or adrenal glands. Optimization of Thyroid hormones, Testosterone, HGH, Vit D  and B12 along with iron supplements, Coq10 and Omega-3 is the multipronged approach of BHRT.

FIBROMYALGIA

Fibromyalgia is a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues. Researchers believe that fibromyalgia amplifies painful sensations by affecting the way your brain processes pain signals.

Symptoms sometimes begin after a physical trauma, surgery, infection or significant psychological stress. In other cases, symptoms gradually accumulate over time with no single triggering event.

The main fibromyalgia signs and symptoms include deep muscle pain, painful tender points, and morning stiffness. Other major symptoms of fibromyalgia include sleep problems, fatigue, and anxiety. In order to make an accurate diagnosis, your doctor will need to review your symptoms and signs of fibromyalgia.

Women are much more likely to develop fibromyalgia than are men. Many people who have fibromyalgia also have tension headaches, temporomandibular joint (TMJ) disorders, irritable bowel syndrome, anxiety and depression.

Treatment of Fibromyalgia involves Optimization of Thyroid hormones, Testosterone, HGH, Vit D  and B12 along with iron supplements, Coq10 and Omega-3.

Exercise, Yoga, Meditation and stress-reduction measures also may help.

DIABETES MELLITUS

Effective management of Diabetes goes beyond the control of Blood Sugar Level. The approach to this disease management is to focus on balancing key metabolic parameters in the body and mitigate the risk of long term complications of the disease such as Retinopathy, Nephropathy, Neuropathy, Stroke, Hypertension, cardiovascular diseas e and Dementia. This involves recognizing and early treatment of Insulin resistance, Optimization of Thyroid and sex hormones, balancing of metabolic parameters, Optimizing key Vitamins along with Diet and exercise.

BHRT AND HEART DISEASE

Role of Testosterone:

“Restoring normal healthy levels of testosterone may be helpful in preventing heart disease”

Chronic heart failure (CHF) is a disabling disease characterized by exercise intolerance and breathlessness. Disease progression arises from prolonged neurohormonal and pro-inflammatory cytokine activation and is associated with a metabolic shift favoring catabolism, vasodilator incapacity, and loss of skeletal muscle bulk and function. In men, androgens are important determinants of anabolic function and physical strength.

Androgens also possess anti-inflammatory and vasodilatory properties. In addition, testosterone has been shown to:

  • Augment cardiac output acutely in men with CHF.
  • Low plasma concentrations of testosterone have been described in men with CHF, and correlate positively with cardiac output.
  • Relative hypotestosteronaemia could contribute to clinical features of muscle wasting and exercise intolerance, inflammatory cytokine activation and impaired vasodilatation, and progression of heart failure.

The heart and blood vessels have a rich supply of testosterone receptors. These receptors are present in the aorta and peripheral blood vessels as well as in ventricular and atrial cells, including the normal male and female left ventricle.

Role of Estrogen and Progesterone: 

  • Estradiol is believed to have a positive effect on the inner layer of artery wall, helping to keep blood vessels flexible.
  • Estradiol significantly reduces the risk of New-Onset Diabetes, a risk factor for Myocardial infection.
  • Progesterone inhibits macrophage lipid synthesis, thereby inhibiting atherosclerosis.
  • Progesterone is not only anti-atherogenic but also protects against coronary artery spasm.
  • Postmenopausal Estradiol and Progesterone Replacement Therapy decreases risk of Coronary Heart Disease.

Role of Belle-OMEGA+  =  Fish Oil Omega3 Fatty Acids and antioxidants:

Role of Belle-OMEGA+  =  Fish Oil Omega3 Fatty Acids and other anti oxidants are integral to BHRT. They help prevent coronary heart disease (CHD) in healthy people and slow progress of the disease in those who already have it.

  • They lower the risk for arrhythmia, which can lead to sudden cardiac death.
  • They lower triglyceride levels.
  • They lower the growth rate of plaque that clogs blood vessels.
  • They lower blood pressure slightly.
  • They help prevent inflammation of the blood vessels and formation of blood clots.

Vit D and Vit B optimization:

  • A growing number of studies point to vitamin D deficiency as a risk factor for heart attacks, congestive heart failure, peripheral arterial disease (PAD), strokes, and the conditions associated with cardiovascular disease, such as high blood pressure and diabetes.
  • Studies have found a higher risk of death from heart disease in individuals with abnormally low levels of vitamin D.
  • Bringing Vit D to optimal levels can prevent heart disease and support recovery from Chronic heart Failure.
  • B group Vitamin supplementation reduces the risk of heart failure in men reduces the risk of death from stroke and heart disease in women.

Adult growth hormone deficiency (AGHD)

Adult growth hormone deficiency (AGHD) is being recognized increasingly and has been thought to be associated with premature mortality. Pituitary tumors are the commonest cause for AGHD. Growth hormone deficiency (GHD) has been associated with neuropsychiatric-cognitive, cardiovascular, neuromuscular, metabolic, and skeletal abnormalities.

  • Changes in memory, processing speed and attention
  • Lack of well-being
  • Depression
  • Anxiety
  • Social isolation
  • Fatigue
  • Lack of strength
  • Fibromyalgia syndrome
  • Neuromuscular dysfunction
  • Central adiposity
  • Decreased muscle mass
  • Decreased bone density
  • Impaired cardiac function
  • Decreased insulin sensitivity
  • Increased low-density lipoprotein
  • Prothrombotic state
  • Decreased sweating and thermoregulation
  • Accelerated atherogenesis with increased carotid intima–media thickness

Most of these issues can be addressed with growth hormone therapy. Growth hormone is administered subcutaneously once-a-day, titrated to clinical symptoms, signs and IGF-1 (insulin like growth factor-1). It is generally well tolerated at the low-doses used in adults.