BHRT and Heart disease:
Role of Testosterone:
“Restoring normal healthy levels of testosterone may be helpful in preventing heart disease”
Chronic heart failure (CHF) is a disabling disease characterised by exercise intolerance and breathlessness. Disease progression arises from prolonged neurohormonal and pro-inflammatory cytokine activation and is associated with a metabolic shift favoring catabolism, vasodilator incapacity, and loss of skeletal muscle bulk and function. In men, androgens are important determinants of anabolic function and physical strength.
Androgens also possess anti-inflammatory and vasodilatory properties. In addition, testosterone has been shown to:
- Augment cardiac output acutely in men with CHF.
- Low plasma concentrations of testosterone have been described in men with CHF, and correlate positively with cardiac output.
- Relative hypotestosteronaemia could contribute to clinical features of muscle wasting and exercise intolerance, inflammatory cytokine activation and impaired vasodilatation, and progression of heart failure.
The heart and blood vessels have a rich supply of testosterone receptors. These receptors are present in the aorta and peripheral blood vessels as well as in ventricular and atrial cells, including the normal male and female left ventricle.
Role of Estrogen and Progesterone:
- Estradiol is believed to have a positive effect on the inner layer of artery wall, helping to keep blood vessels flexible.
- Estradiol significantly reduces the risk of New-Onset Diabetes, a risk factor for Myocardial infection.
- Progesterone inhibits macrophage lipid synthesis, thereby inhibiting atherosclerosis.
- Progesterone is not only anti-atherogenic but also protects against coronary artery spasm.
- Postmenopausal Estradiol and Progesterone Replacement Therapy decreases risk of Coronary Heart Disease.
Role of Belle-OMEGA+ = Fish Oil Omega3 Fatty Acids and antioxidants:
Role of Belle-OMEGA+ = Fish Oil Omega3 Fatty Acids and other anti oxidants are integral to BHRT. They help prevent coronary heart disease (CHD) in healthy people and slow progress of the disease in those who already have it.
- They lower the risk for arrhythmia, which can lead to sudden cardiac death.
- They lower triglyceride levels.
- They lower the growth rate of plaque that clogs blood vessels.
- They lower blood pressure slightly.
- They help prevent inflammation of the blood vessels and formation of blood clots.
Vit D and Vit B optimization:
- A growing number of studies point tovitamin D deficiency as a risk factor for heart attacks, congestive heart failure, peripheral arterial disease (PAD), strokes, and the conditions associated with cardiovascular disease, such as high blood pressure and diabetes.
- Studies have found a higher risk of death from heart disease in individuals with abnormally low levels of vitamin D.
- Bringing Vit D to optimal levels can prevent heart disease and support recovery from Chronic heart Failure.
- B group Vitamin supplementation reduces the risk of heart failure in men reduces the risk of death from stroke and heart disease in women.